Genomic Imprinting and Environmental Disease Susceptibility
نویسندگان
چکیده
منابع مشابه
Genomic imprinting and environmental disease susceptibility.
Genomic imprinting is one of the most intriguing subtleties of modern genetics. The term "imprinting" refers to parent-of-origin-dependent gene expression. The presence of imprinted genes can cause cells with a full parental complement of functional autosomal genes to specifically express one allele but not the other, resulting in monoallelic expression of the imprinted loci. Genomic imprinting...
متن کاملPolymorphisms, genomic imprinting and cancer susceptibility.
Polymorphisms have been identified in proto-oncogenes and tumor suppressor genes that predispose people to cancer. Recent evidence indicates that genomic imprinting, an epigenetic form of gene regulation that results in uniparental gene expression, can also function as a cancer predisposing event. Thus, cancer susceptibility is increased by both Mendelian inherited genetic and non-Mendelian inh...
متن کاملGenomic Imprinting
BACKGROUND Genomic imprinting is the inheritance out of Mendelian borders. Many of inherited diseases and human development violates Mendelian law of inheritance, this way of inheriting is studied by epigenetics. AIM The aim of this review is to analyze current opinions and options regarding to this way of inheriting. RESULTS Epigenetics shows that gene expression undergoes changes more com...
متن کاملGenomic imprinting
Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated...
متن کاملGenomic imprinting
Genomic imprinting is a normal form of gene regulation that causes a subset of mammalian genes to be expressed from one of the two parental chromosomes. Some imprinted genes are expressed from the maternally inherited chromosomes and others from the paternally inherited chromosomes. This means that the maternal and paternal genomes are not functionally equivalent and is the reason why both a ma...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2000
ISSN: 0091-6765
DOI: 10.2307/3454445